Cholesterol synthesis vs ketone body synthesis
Cytochrome aa3 is so-called due to the presence of two distinct heme a prosthetic groups with heme a being the direct electron donor in the complex IV catalyzed reduction of O2 to H2O. SREBP-1c is also an essential transcription factor downstream of the actions of insulin at the level of carbohydrate and lipid metabolism.
The primary sterol regulating HMGR degradation is cholesterol itself. Condensation of two acetyl CoAs using thiolase to form acetoacetyl CoA. This shared motif is called the sterol sensing domain SSD and as a consequence of this domain SCAP functions as the cholesterol sensor in the protein complex.
Functional DHCR7 protein is a ACC catalyzes the formation of malonyl-CoA 4.