Synthesis of nicorandil Potassium Channel Modulators

Synthesis of nicorandil, potassium calcium-activated channel subfamily m alpha 1

Apart essay heroic deed the specific medicinal product interaction information described above, interaction studies with DuoPlavin and some medicinal products commonly administered in patients with atherothrombotic disease have not been performed.

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Gastrointestinal GI DuoPlavin should be used with caution in patients with a history of peptic ulcer or gastroduodenal haemorrhage or minor upper GI symptoms as this may be due to gastric ulceration which may lead to gastric bleeding. A pharmacodynamic interaction between DuoPlavin and heparin is possible, leading to increased risk of bleeding.

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Patients with a confirmed diagnosis of acquired haemophilia should be managed and treated by specialists, and clopidogrel should be discontinued. Monitoring for signs of hypersensitivity in patients with a known allergy to thienopyridines is advised.

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